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Whats new in 4.116?

What's new in 4.116?

Posted: Nov 5 2026

🍁 Scout 4.116 is here! 🍁 This release adds new resources and scores for variant interpretation, improves repeat-expansion workflows, and brings useful updates to ClinVar submissions, ACMG classification, and variant browsing.

Highlights

  • More information for variant interpretation. Scout now parses and displays AlphaGenome Variant Impact (AVI) and AlphaMissense scores. For hg38 variants, you can also follow links to dbNSFP and gnomAD long-read sequencing (LRS). New gnomAD frequency fields include WES, homozygous alternate counts, and allele counts, with more significant digits for frequency values.

  • Improved STR workflows. STR variants now link to STRchive. Custom images can also be matched to both STR repetitions (REPID) and tandem repeat IDs (TRID), so matching images can be discovered and associated with the corresponding variants.

  • More detail in ACMG classification. The ACMG classification form now shows the Bayesian point contribution for each criterion, making the contribution of individual criteria easier to review.

  • More control over ClinVar submissions. ClinVar submissions can once again be deleted from the ClinVar portal through the API.

Also included

  • Variants with duplicate IDs in a loading batch now retain the highest-scoring variant.
  • Links from the Dark Regions page to SNVs and SVs are no longer restricted by the gene panels selected on that page.
  • Dark Regions and SMN have been moved to a separate blueprint.
  • Non-numeric SuperDups fraction match annotations no longer prevent variant loading.
  • STR genotype depth parsing and parsing of unexpectedly haploid genotype arrays have been fixed.
  • STR variants with identical sort keys are now returned consistently, preventing variants from being missed during pagination.
  • Documentation now covers external services accessed by a Scout installation, the README overview and supported-pipeline FAQ link have been updated, and automation is now available for building and uploading a stage-branch CLI Docker image.